This replica of the body's blood factory is made entirely with human cells. Breakthroughs, discoveries, and DIY tips sent every weekday. Without even thinking about it, the bone marrow in your body is churning out billions of cells every single day. Bone marrow is our body's strong and silent "blood factory," working hard in the background while heart pumps and brain controls. The spongy marrow really gets attention during a blood cancer diagnosis or when this crucial system stops working properly.

This paper presents a comprehensive methodology and comparative performance analysis for the automated classification and object detection of peripheral blood cells (PBCs) in microscopic images. Addressing the critical challenge of data scarcity and heterogeneity, robust data pipeline was first developed to standardize and merge four public datasets (PBC, BCCD, Chula, Sickle Cell) into a unified resource. Then employed a state-of-the-art Faster R-CNN object detection framework, leveraging a ResNet-50-FPN backbone. Comparative training rigorously evaluated a randomly initialized baseline model (Regimen 1) against a Transfer Learning Regimen (Regimen 2), initialized with weights pre-trained on the Microsoft COCO dataset. The results demonstrate that the Transfer Learning approach achieved significantly faster convergence and superior stability, culminating in a final validation loss of 0.08666, a substantial improvement over the baseline. This validated methodology establishes a robust foundation for building high-accuracy, deployable systems for automated hematological diagnosis.

Red blood cells (RBCs) are essential to human health, and their precise morphological analysis is important for diagnosing hematological disorders. Despite the promise of foundation models in medical diagnostics, comprehensive AI solutions for RBC analysis remain scarce. We present RedDino, a self-supervised foundation model designed for RBC image analysis. RedDino uses an RBC-specific adaptation of the DINOv2 self-supervised learning framework and is trained on a curated dataset of 1.25 million RBC images from diverse acquisition modalities and sources. Extensive evaluations show that RedDino outperforms existing state-of-the-art models on RBC shape classification. Through assessments including linear probing and nearest neighbor classification, we confirm its strong feature representations and generalization ability. Our main contributions are: (1) a foundation model tailored for RBC analysis, (2) ablation studies exploring DINOv2 configurations for RBC modeling, and (3) a detailed evaluation of generalization performance. RedDino addresses key challenges in computational hematology by capturing nuanced morphological features, advancing the development of reliable diagnostic tools. The source code and pretrained models for RedDino are available at https://github.com/Snarci/RedDino, and the pretrained models can be downloaded from our Hugging Face collection at https://huggingface.co/collections/Snarcy/reddino-689a13e29241d2e5690202fc

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We then annotated ten thousand WBC images with these attributes, resulting in 113k labels (11 attributes x 10.3k images). Annotating at this level of detail and scale is unprecedented, offering unique value to AI in pathology. Moreover, we conduct experiments to predict these attributes from cell images, and also demonstrate specific applications that can benefit from our detailed annotations.

Biomedical datasets are often constrained by stringent privacy requirements and frequently suffer from severe class imbalance. These two aspects hinder the development of accurate machine learning models. While generative AI offers a promising solution, producing synthetic images of sufficient quality for training robust classifiers remains challenging. This work addresses the classification of individual white blood cells, a critical task in diagnosing hematological malignancies such as acute myeloid leukemia (AML). We introduce CytoDiff, a stable diffusion model fine-tuned with LoRA weights and guided by few-shot samples that generates high-fidelity synthetic white blood cell images. Our approach demonstrates substantial improvements in classifier performance when training data is limited. Using a small, highly imbalanced real dataset, the addition of 5,000 synthetic images per class improved ResNet classifier accuracy from 27\% to 78\% (+51\%). Similarly, CLIP-based classification accuracy increased from 62\% to 77\% (+15\%). These results establish synthetic image generation as a valuable tool for biomedical machine learning, enhancing data coverage and facilitating secure data sharing while preserving patient privacy. Paper code is publicly available at https://github.com/JanCarreras24/CytoDiff.

While analysing rare blood cell aggregates remains challenging in automated h aematology, they could markedly advance label - free functional diagnostics. Conventional flow cytometers efficiently perform cell counting with leukocyte differentials but fail to identify aggregates with flagged results, requiring manual reviews. Quantitat ive phase imaging flow cytometry captures detailed aggregate morphologies, but clinical use is hampered by massive data storage and offline processing. Incorporating "hidden" biom arkers into routine haematology panels would significantly improve diagnostics with out flagged results. We present RT - HAD, a n end - to - end deep learning - based image and data processing framework for off - axis digital holographic microscopy (DHM), which combines physics - consistent holographic reconstruction and detection, represent ing each blood cell in a graph to recognize aggregates . RT - HAD processes >30 GB of image data on - the - fly with turnaround time of <1.5 min and error rate of 8.9% in platelet aggregate detection, which matches acceptable laboratory error rates of haematology biomarkers and solves the "big data" challenge for point - of - care diagnostics .

Federated Learning (FL) is a distributed machine learning paradigm enabling collaborative model training across decentralized clients while preserving data privacy. In this paper, we revisit the stability of the vanilla FedA vg algorithm under diverse conditions. Despite its conceptual simplicity, FedA vg exhibits remarkably stable performance compared to more advanced FL techniques. Our experiments assess the performance of various FL methods on blood cell and skin lesion classification tasks using Vision Transformer (ViT). Additionally, we evaluate the impact of different representative classification models and analyze sensitivity to hyperparameter variations. The results consistently demonstrate that, regardless of dataset, classification model employed, or hyperparameter settings, FedAvg maintains robust performance. Given its stability, robust performance without the need for extensive hyperparameter tuning, FedAvg is a safe and efficient choice for FL deployments in resource-constrained hospitals handling medical data. These findings underscore the enduring value of the vanilla FedAvg approach as a trusted baseline for clinical practice.

The complexities inherent to leukemia, multifaceted cancer affecting white blood cells, pose considerable diagnostic and treatment challenges, primarily due to reliance on laborious morphological analyses and expert judgment that are susceptible to errors. Addressing these challenges, this study presents a refined, comprehensive strategy leveraging advanced deep-learning techniques for the classification of leukemia subtypes. We commence by developing a hierarchical label taxonomy, paving the way for differentiating between various subtypes of leukemia. The research further introduces a novel hierarchical approach inspired by clinical procedures capable of accurately classifying diverse types of leukemia alongside reactive and healthy cells. An integral part of this study involves a meticulous examination of the performance of Convolutional Neural Networks (CNNs) and Vision Transformers (ViTs) as classifiers. The proposed method exhibits an impressive success rate, achieving approximately 90\% accuracy across all leukemia subtypes, as substantiated by our experimental results. A visual representation of the experimental findings is provided to enhance the model's explainability and aid in understanding the classification process.